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Gene Ontology Classifications
breast cancer 2

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GO curators for mouse genes have assigned the following annotations to the gene product of Brca2. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of November 16, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Bernard-Gallon DJ et al. (2001) Brca1 and Brca2 protein expression patterns in different tissues of murine origin. Int J Oncol, 18:271-80. (PubMed:11172592)
  2. Bowman-Colin C et al. (2013) Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proc Natl Acad Sci U S A, 110:8632-7. (PubMed:23657012)
  3. Connor F et al. (1997) Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation. Nat Genet, 17:423-30. (PubMed:9398843)
  4. Daniels MJ et al. (2004) Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2. Science, 306:876-9. (PubMed:15375219)
  5. Flores KG et al. (2002) Thymic model for examining BRCA2 expression and function. Mol Carcinog, 35:103-9. (PubMed:12410562)
  6. Frappart PO et al. (2007) BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J, 26:2732-42. (PubMed:17476307)
  7. Gudmundsdottir K et al. (2004) DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells. EMBO Rep, 5:989-93. (PubMed:15359272)
  8. Hay T et al. (2005) Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells. Oncogene, 24:3842-6. (PubMed:15735671)
  9. Houghtaling S et al. (2003) Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes Dev, 17:2021-35. (PubMed:12893777)
  10. Lomonosov M et al. (2003) Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein. Genes Dev, 17:3017-22. (PubMed:14681210)
  11. Ludwig T et al. (1997) Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev, 11:1226-41. (PubMed:9171368)
  12. Miyakawa T et al. (1996) Radial maze performance, open-field and elevated plus-maze behaviors in Fyn-kinase deficient mice: further evidence for increased fearfulness. Brain Res Mol Brain Res, 37:145-50. (PubMed:8738145)
  13. Morimatsu M et al. (1998) Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to gamma-radiation and premature senescence. Cancer Res, 58:3441-7. (PubMed:9699678)
  14. Navarro S et al. (2006) Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1. Mol Ther, 14:525-35. (PubMed:16859999)
  15. Patel KJ et al. (1998) Involvement of Brca2 in DNA repair. Mol Cell, 1:347-57. (PubMed:9660919)
  16. Sarkisian CJ et al. (2001) Analysis of murine brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals. J Biol Chem, 276:37640-8. (PubMed:11477095)
  17. Sharan SK et al. (1997) Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 [see comments] Nature, 386:804-10. (PubMed:9126738)
  18. Sharan SK et al. (2004) BRCA2 deficiency in mice leads to meiotic impairment and infertility. Development, 131:131-42. (PubMed:14660434)
  19. Stark JM et al. (2004) Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Mol Cell Biol, 24:9305-16. (PubMed:15485900)
  20. Suzuki A et al. (1997) Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev, 11:1242-52. (PubMed:9171369)
  21. Yang H et al. (2002) BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science, 297:1837-48. (PubMed:12228710)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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