Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mapkapk2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Mapkapk2
  • participates in the following biological processes:
    • inner ear development ^[3]
    • protein phosphorylation ^[1]
  • performs the following molecular functions:
    • protein serine/threonine kinase activity ^{[1, 5, 7]}
  • is located in the following cellular components:
    • cytoplasm ^{[1, 6]}
    • nucleus ^{[1, 6]}
• The gene product of Mapkapk2 has been shown to bind to the gene products of Rps6ka3. ^[7]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Mapkapk2
  • participates in the following biological processes:
    • inflammatory response ^[2]
    • macropinocytosis ^[7]
    • mRNA stabilization ^[4]
    • regulation of interleukin-6 production ^[2]
    • regulation of tumor necrosis factor production ^[2]
    • response to lipopolysaccharide ^{[2, 7]}
    • toll-like receptor signaling pathway ^[7]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Mapkapk2:
  • participates in the following biological processes:
    • 3'-UTR-mediated mRNA stabilization
    • cellular response to vascular endothelial growth factor stimulus
    • G2/M transition DNA damage checkpoint
    • peptidyl-serine phosphorylation
    • regulation of tumor necrosis factor production
    • response to DNA damage stimulus
    • response to stress
    • vascular endothelial growth factor receptor signaling pathway
  • performs the following molecular functions:
    • protein serine/threonine kinase activity
  • is located in the following cellular components:
    • cytoplasm
    • nucleus

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Summary text based on GO annotations supported by structural data

• Mapkapk2 encodes a protein or proteins that contain the following InterPro domains: Protein kinase, ATP binding site, Protein kinase, catalytic domain, Protein kinase-like domain, Serine/threonine- / dual-specificity protein kinase, catalytic domain, Serine/threonine-protein kinase, active site, indicating that the gene product:
  • performs the following molecular functions:
    • ATP binding
    • protein kinase activity
    • transferase activity, transferring phosphorus-containing groups

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mapkapk2 indicates that it:
  • participates in the following biological processes:
    • phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • nucleotide binding
    • transferase activity

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References

1. Engel K et al. (1998) Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation. EMBO J, 17:3363-71. (PubMed:9628873)
2. Kotlyarov A et al. (1999) MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis [see comments] Nat Cell Biol, 1:94-7. (PubMed:10559880)
3. Lu CC et al. (2011) Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci, 31:10903-18. (PubMed:21795542)
4. Neininger A et al. (2002) MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels. J Biol Chem, 277:3065-8. (PubMed:11741878)
5. Rousseau S et al. (2002) Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. EMBO J, 21:6505-14. (PubMed:12456657)
6. Schumacher S et al. (2004) Scaffolding by ERK3 regulates MK5 in development. EMBO J, 23:4770-4779. (PubMed:15538386)
7. Zaru R et al. (2007) The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat Immunol, 8:1227-35. (PubMed:17906627)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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