GO curators for mouse genes have assigned the following annotations to the gene product of Trim24. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of May 8, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.Summary from NCBI RefSeq
The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and binding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and Braf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]Summary text based on GO annotations supported by experimental evidence in mouse
Researchers have inferred from direct assay, that the gene product of Trim24
participates in the following biological processes:
The gene product of Trim24 has been shown to bind to the gene products of Brd7, Cbx1. [5, 6, 12] Researchers have inferred, based on physical interactions, that the gene product of Trim24
Allton K et al. (2009) Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A, 106:11612-6. (PubMed:19556538)
Ignat M et al. (2008) Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha. Proc Natl Acad Sci U S A, 105:2598-603. (PubMed:18287084)
Khetchoumian K et al. (2004) TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J Biol Chem, 279:48329-41. (PubMed:15322135)
Khetchoumian K et al. (2007) Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet, 39:1500-6. (PubMed:18026104)
Kikuchi M et al. (2009) TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells. Biochim Biophys Acta, 1793:1828-36. (PubMed:19909775)
Le Douarin B et al. (1996) A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J, 15:6701-15. (PubMed:8978696)
LeDouarin B et al. (1995) The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J, 14:2020-33. (PubMed:7744009)
Niederreither K et al. (1999) Expression of the transcriptional intermediary factor TIF1alpha during mouse development and in the reproductive organs Mech Dev, 88:111-7. (PubMed:10525195)
Nielsen AL et al. (1999) Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. EMBO J, 18:6385-95. (PubMed:10562550)
Remboutsika E et al. (1999) The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin. J Cell Sci, 112:1671-83. (PubMed:10318760)
Zhong S et al. (1999) A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nat Genet, 23:287-95. (PubMed:10610177)
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