Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA binding activity; protein kinase activity; and transcription coactivator activity. Involved in epithelial to mesenchymal transition; positive regulation of DNA methylation-dependent heterochromatin formation; and positive regulation of DNA-templated transcription. Acts upstream of or within several processes, including convergent extension involved in axis elongation; negative regulation of DNA demethylation; and regulation of macromolecule biosynthetic process. Located in nucleoplasm. Part of RNA polymerase II transcription regulator complex; euchromatin; and heterochromatin. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and limb primordium. Orthologous to human TRIM28 (tripartite motif containing 28).