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Gene Ontology Classifications
actinin alpha 2

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GO curators for mouse genes have assigned the following annotations to the gene product of Actn2. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Ajima R et al. (2008) Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations. Genes Cells, 13:987-99. (PubMed:18761673)
  2. Beqqali A et al. (2010) CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. J Cell Sci, 123:1141-50. (PubMed:20215401)
  3. Collin GB et al. (2012) The Alstrom syndrome protein, ALMS1, interacts with alpha-actinin and components of the endosome recycling pathway. PLoS One, 7:e37925. (PubMed:22693585)
  4. Collins MO et al. (2006) Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome. J Neurochem, 97 Suppl 1:16-23. (PubMed:16635246)
  5. Durham JT et al. (2006) Myospryn is a direct transcriptional target for MEF2A that encodes a striated muscle, alpha-actinin-interacting, costamere-localized protein. J Biol Chem, 281:6841-9. (PubMed:16407236)
  6. Frey N et al. (2000) Calsarcins, a novel family of sarcomeric calcineurin-binding proteins Proc Natl Acad Sci U S A, 97:14632-7. (PubMed:11114196)
  7. Gokhin DS et al. (2010) Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology. J Cell Biol, 189:95-109. (PubMed:20368620)
  8. Heineke J et al. (2005) Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc. Proc Natl Acad Sci U S A, 102:1655-60. (PubMed:15665106)
  9. Huang SM et al. (2004) The enhancement of nuclear receptor transcriptional activation by a mouse actin-binding protein, alpha actinin 2. J Mol Endocrinol, 32:481-96. (PubMed:15072553)
  10. Husi H et al. (2000) Proteomic analysis of NMDA receptor-adhesion protein signaling complexes [see comments] Nat Neurosci, 3:661-9. (PubMed:10862698)
  11. Itoh S et al. (2006) Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation, 113:1787-98. (PubMed:16585392)
  12. Keicher C et al. (2004) Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. Biochem Biophys Res Commun, 324:308-16. (PubMed:15465019)
  13. Lu L et al. (2007) Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2. Circ Res, 100:112-20. (PubMed:17110593)
  14. Nakazawa T et al. (2006) NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J, 25:2867-77. (PubMed:16710293)
  15. Radke MH et al. (2007) Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy. Proc Natl Acad Sci U S A, 104:3444-9. (PubMed:17360664)
  16. Robison AJ et al. (2005) Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. J Biol Chem, 280:35329-36. (PubMed:16120608)
  17. Schiaffino S et al. (1996) Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev, 76:371-423. (PubMed:8618961)
  18. Steiner-Champliaud MF et al. (2010) BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin. Exp Cell Res, 316:297-313. (PubMed:19932097)
  19. Yuan B et al. (2014) A Cardiomyocyte-Specific Wdr1 Knockout Demonstrates Essential Functional Roles for Actin Disassembly during Myocardial Growth and Maintenance in Mice. Am J Pathol, 184:1967-80. (PubMed:24840128)
  20. Zhou Q et al. (1999) Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C. J Biol Chem, 274:19807-13. (PubMed:10391924)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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