Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Grk5. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Grk5:
  • participates in the following biological processes:
    • desensitization of G-protein coupled receptor protein signaling pathway
    • negative regulation of apoptotic process
    • protein autophosphorylation
    • regulation of G-protein coupled receptor protein signaling pathway
    • tachykinin receptor signaling pathway
  • performs the following molecular functions:
    • protein serine/threonine kinase activity
  • is located in the following cellular components:
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Grk5 encodes a protein or proteins that contain the following InterPro domains: AGC-kinase, C-terminal, GPCR kinase, Protein kinase, ATP binding site, Protein kinase, catalytic domain, Protein kinase-like domain, Regulator of G protein signalling, Regulator of G protein signalling superfamily, Serine/threonine- / dual-specificity protein kinase, catalytic domain, indicating that the gene product:
  • participates in the following biological processes:
    • protein phosphorylation
    • signal transduction
    • termination of G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • ATP binding
    • G-protein coupled receptor kinase activity
    • protein kinase activity
    • transferase activity, transferring phosphorus-containing groups

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Grk5 indicates that it:
  • participates in the following biological processes:
    • apoptotic process
    • phosphorylation
    • Wnt receptor signaling pathway
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • lipid binding
    • nucleotide binding
    • transferase activity
  • is located in the following cellular components:
    • cytoplasm
    • membrane
    • nucleus
• Grk5 has been associated with the Enzyme Commission numbers: 2.7.11.16, which implies that the gene product:
  • performs the following molecular functions:
    • G-protein coupled receptor kinase activity

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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