Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fzd8. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 27, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Fzd8
  • participates in the following biological processes:
    • canonical Wnt receptor signaling pathway ^[5]
    • negative regulation of transcription from RNA polymerase II promoter ^[3]
    • positive regulation of JUN kinase activity ^[11]
    • positive regulation of transcription from RNA polymerase II promoter ^[3]
  • is located in the following cellular components:
    • plasma membrane ^[9]
• The gene product of Fzd8 has been shown to bind to the gene products of Gopc, Rspo1, Rspo3, Ryk. ^{[4, 5, 10]} Researchers have inferred, based on physical interactions, that the gene product of Fzd8
  • participates in the following biological processes:
    • signal transduction ^[4]
  • performs the following molecular functions:
    • PDZ domain binding ^[10]
    • receptor binding ^[8]
    • Wnt-activated receptor activity ^[4]
    • Wnt-protein binding ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Fzd8
  • participates in the following biological processes:
    • canonical Wnt receptor signaling pathway ^{[1, 2, 6]}
    • positive regulation of protein phosphorylation ^[2]
    • T cell differentiation in thymus ^[6]
• Researchers have inferred, based on genetic interactions, that the gene product of Fzd8
  • participates in the following biological processes:
    • canonical Wnt receptor signaling pathway based on interactions with Wnt3a ^[7]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Fzd8:
  • participates in the following biological processes:
    • axonogenesis
    • brain development
    • embryo development
    • gonad development
    • regulation of transcription from RNA polymerase II promoter
    • vasculature development
  • performs the following molecular functions:
    • PDZ domain binding
    • ubiquitin protein ligase binding
  • is located in the following cellular components:
    • cell projection
    • cytoplasm

---

Summary text based on GO annotations supported by structural data

• Fzd8 encodes a protein or proteins that contain the following InterPro domains: Frizzled domain, Frizzled protein, Frizzled-8, Frizzled/secreted frizzled-related protein, GPCR, family 2-like, indicating that the gene product:
  • participates in the following biological processes:
    • cell surface receptor signaling pathway
    • Wnt receptor signaling pathway
  • performs the following molecular functions:
    • transmembrane signaling receptor activity
  • is located in the following cellular components:
    • membrane

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Fzd8 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • multicellular organismal development
    • Wnt receptor signaling pathway
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • Golgi apparatus
    • integral to membrane
    • membrane

---

References

1. Brennan K et al. (2004) Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins. Oncogene, 23:4873-84. (PubMed:15064719)
2. Gonzalez-Sancho JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol Cell Biol, 24:4757-68. (PubMed:15143170)
3. Liu Y et al. (2007) Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc Natl Acad Sci U S A, 104:3859-64. (PubMed:17360443)
4. Lu W et al. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell, 119:97-108. (PubMed:15454084)
5. Nam JS et al. (2006) Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J Biol Chem, 281:13247-57. (PubMed:16543246)
6. Staal FJ et al. (2001) Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur J Immunol, 31:285-93. (PubMed:11265645)
7. Takada R et al. (2005) Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation. Genes Cells, 10:919-28. (PubMed:16115200)
8. Tamai K et al. (2000) LDL-receptor-related proteins in Wnt signal transduction. Nature, 407:530-5. (PubMed:11029007)
9. Xu Q et al. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell, 116:883-95. (PubMed:15035989)
10. Yao R et al. (2001) Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. Biochem Biophys Res Commun, 286:771-8. (PubMed:11520064)
11. Yao R et al. (2004) MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. Oncogene, 23:6023-30. (PubMed:15195140)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---