Automated description from the Alliance of Genome Resources (Release 3.1.1)
Predicted to have activating transcription factor binding activity; protein C-terminus binding activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated and response to interferon-gamma. Predicted to localize to PML body; cell surface; and cytosol. Is expressed in bladder; central nervous system; and retina. Used to study MHC class II deficiency and osteoporosis. Human ortholog(s) of this gene implicated in Addison's disease; MHC class II deficiency; autoimmune hypersensitivity disease (multiple); myocardial infarction; and rheumatoid arthritis (multiple). Orthologous to human CIITA (class II major histocompatibility complex transactivator).