Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nrtn. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Nrtn
  • performs the following molecular functions:
    • growth factor activity ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Nrtn
  • participates in the following biological processes:
    • nerve development ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Nrtn
  • participates in the following biological processes:
    • transmembrane receptor protein tyrosine kinase signaling pathway based on interactions with Gfra2, Ret ^[1]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Nrtn:
  • participates in the following biological processes:
    • neural crest cell migration
    • neuron projection development
  • performs the following molecular functions:
    • growth factor activity
  • is located in the following cellular components:
    • axon

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Nrtn indicates that it:
  • is located in the following cellular components:
    • extracellular region

---

References

1. Baloh RH et al. (1998) GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc Natl Acad Sci U S A, 95:5801-6. (PubMed:9576965)
2. Heuckeroth RO et al. (1999) Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons [see comments] Neuron, 22:253-63. (PubMed:10069332)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---