Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Apbb2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 7, 2006. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Apbb2
  • participates in the following biological processes:
    • cell cycle arrest ^[1]
    • negative regulation of cell growth ^[1]
    • negative regulation of S phase of mitotic cell cycle ^[1]
    • positive regulation of apoptotic process ^[3]
    • regulation of transcription, DNA-dependent ^[1]
  • performs the following molecular functions:
    • transcription factor binding ^[1]
  • is located in the following cellular components:
    • cytoplasm ^[3]
    • nucleus ^[1]
• The gene product of Apbb2 has been shown to bind to the gene products of Mapk8. ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Apbb2
  • participates in the following biological processes:
    • axon guidance based on interactions with Apbb1 ^[2]
    • extracellular matrix organization based on interactions with Apbb1 ^[2]
    • negative regulation of apoptotic process based on interactions with Fasl, Tnf ^[3]
    • neuron migration based on interactions with Apbb1 ^[2]

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References

1. Bruni P et al. (2002) Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression. J Biol Chem, 277:35481-8. (PubMed:12089154)
2. Guenette S et al. (2006) Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. EMBO J, 25:420-31. (PubMed:16407979)
3. Hsu LJ et al. (2005) Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. Biochem Biophys Res Commun, 327:415-23. (PubMed:15629131)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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