Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Aldh7a1. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. [provided by RefSeq, Jan 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Aldh7a1
  • is located in the following cellular components:
    • mitochondrion ^{[1, 2]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Aldh7a1:
  • participates in the following biological processes:
    • oxidation-reduction process
  • performs the following molecular functions:
    • L-aminoadipate-semialdehyde dehydrogenase activity
  • is located in the following cellular components:
    • cytoplasm
    • extracellular vesicular exosome
    • mitochondrion

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Summary text based on GO annotations supported by structural data

• Aldh7a1 encodes a protein or proteins that contain the following InterPro domains: Aldehyde dehydrogenase domain, Aldehyde dehydrogenase, C-terminal, Aldehyde dehydrogenase, conserved site, Aldehyde dehydrogenase, N-terminal, Aldehyde/histidinol dehydrogenase, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • oxidoreductase activity
    • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Aldh7a1 indicates that it:
  • performs the following molecular functions:
    • oxidoreductase activity
  • is located in the following cellular components:
    • nucleus
• Aldh7a1 has been associated with the Enzyme Commission numbers: 1.2.1.3, 1.2.1.31, 1.2.1.8, which implies that the gene product:
  • performs the following molecular functions:
    • aldehyde dehydrogenase (NAD) activity
    • betaine-aldehyde dehydrogenase activity

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References

1. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
2. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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