Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Bin1. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 2011]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Bin1
  • is located in the following cellular components:
    • nucleus ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Bin1
  • participates in the following biological processes:
    • muscle cell differentiation ^[1]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Bin1:
  • participates in the following biological processes:
    • positive regulation of endocytosis
    • positive regulation of GTPase activity
  • performs the following molecular functions:
    • GTPase binding
    • protein complex binding
    • protein heterodimerization activity
  • is located in the following cellular components:
    • axon terminus
    • cerebellar mossy fiber
    • cytoplasm
    • synaptic vesicle
    • varicosity

---

Summary text based on GO annotations supported by structural data

• Bin1 encodes a protein or proteins that contain the following InterPro domains: Amphiphysin, Amphiphysin, isoform 2, BAR domain, Src homology-3 domain, Variant SH3, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of endocytosis

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Bin1 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • endocytosis
    • multicellular organismal development

---

References

1. Mao NC et al. (1999) The murine Bin1 gene functions early in myogenesis and defines a new region of synteny between mouse chromosome 18 and human chromosome 2. Genomics, 56:51-8. (PubMed:10036185)
2. Sakamuro D et al. (1996) BIN1 is a novel MYC-interacting protein with features of a tumour suppressor [see comments] Nat Genet, 14:69-77. (PubMed:8782822)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---