Gene Ontology Classifications

Symbol
Name
ID

Gab1
growth factor receptor bound protein 2-associated protein 1
MGI:108088

Go Annotations as Summary Text (Tabular View) (GO Graph)

Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables signaling adaptor activity. Involved in epidermal growth factor receptor signaling pathway and positive regulation of cell migration by vascular endothelial growth factor signaling pathway. Acts upstream of or within several processes, including cell surface receptor signaling pathway; labyrinthine layer development; and positive regulation of MAPK cascade. Located in cytoplasm. Is active in cell cortex. Is expressed in several structures, including brain; gonad; gut; hemolymphoid system gland; and primordial germ cell. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to human GAB1 (GRB2 associated binding protein 1).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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