Automated description from the Alliance of Genome Resources
Exhibits several functions, including DNA binding activity; primary miRNA binding activity; and protein methyltransferase activity. Involved in several processes, including macromolecule methylation; negative regulation of cell differentiation; and regulation of transcription, DNA-templated. Localizes to the ESC/E(Z) complex and pronucleus. Colocalizes with the nuclear chromatin. Used to study Weaver syndrome and acute lymphocytic leukemia. Human ortholog(s) of this gene implicated in Weaver syndrome and hematologic cancer (multiple). Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit).