Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits several functions, including nucleic acid binding activity; protein methyltransferase activity; and transcription corepressor activity. Involved in several processes, including macromolecule methylation; negative regulation of cell differentiation; and regulation of transcription, DNA-templated. Localizes to ESC/E(Z) complex; chromatin silencing complex; and pronucleus. Colocalizes with nuclear chromatin. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study B-cell lymphoma; Weaver syndrome; and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in Weaver syndrome; glioblastoma multiforme; hematologic cancer (multiple); and stomach cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit).