Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including histone H3K27 methyltransferase activity; nucleic acid binding activity; and transcription corepressor activity. Involved in B cell differentiation; facultative heterochromatin formation; and regulation of circadian rhythm. Acts upstream of or within several processes, including cardiac muscle hypertrophy in response to stress; negative regulation of DNA-templated transcription; and negative regulation of cell differentiation. Located in pronucleus. Part of ESC/E(Z) complex; chromatin silencing complex; and pericentric heterochromatin. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Used to study B-cell lymphoma; Weaver syndrome; and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Weaver syndrome; gastrointestinal system cancer (multiple); glioblastoma; hematologic cancer (multiple); and renal Wilms' tumor. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit).
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