Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tfam. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Tfam
  • is located in the following cellular components:
    • mitochondrion ^{[1, 2, 3]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Tfam
  • participates in the following biological processes:
    • mitochondrial respiratory chain complex assembly ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tfam:
  • participates in the following biological processes:
    • positive regulation of transcription, DNA-dependent
    • transcription from mitochondrial promoter
    • transcription initiation from mitochondrial promoter
  • performs the following molecular functions:
    • chromatin binding
    • DNA binding
    • DNA binding, bending
    • heat shock protein binding
    • mitochondrial light strand promoter sense binding
    • sequence-specific DNA binding transcription factor activity
  • is located in the following cellular components:
    • mitochondrial nucleoid
    • mitochondrion

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tfam indicates that it:
  • participates in the following biological processes:
    • transcription, DNA-dependent
  • is located in the following cellular components:
    • nucleus

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References

1. Larsson NG et al. (1996) A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein. Nat Genet, 13:296-302. (PubMed:8673128)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
4. Wang J et al. (2001) Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression. Proc Natl Acad Sci U S A, 98:4038-43. (PubMed:11259653)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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