Automated description from the Alliance of Genome Resources
Exhibits mitochondrial promoter sequence-specific DNA binding activity. Involved in mitochondrial respiratory chain complex assembly and mitochondrial transcription. Localizes to the mitochondrial nucleoid. Used to study Kearns-Sayre syndrome and Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Orthologous to human TFAM (transcription factor A, mitochondrial).