Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gadd45a. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Gadd45a
  • participates in the following biological processes:
    • negative regulation of protein kinase activity ^[3]
    • regulation of cell cycle ^[3]
  • performs the following molecular functions:
    • core promoter binding ^[1]
  • is located in the following cellular components:
    • nucleus ^[2]
• The gene product of Gadd45a has been shown to bind to the gene products of Ccnb1, Cdk1, Pcna. ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Gadd45a
  • participates in the following biological processes:
    • centrosome cycle based on interactions with Brca1 ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gadd45a:
  • participates in the following biological processes:
    • cellular response to ionizing radiation
    • positive regulation of reactive oxygen species metabolic process
    • signal transduction in response to DNA damage
  • is located in the following cellular components:
    • nucleus

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Summary text based on GO annotations supported by structural data

• Gadd45a encodes a protein or proteins that contain the following InterPro domains: Growth arrest and DNA damage-inducible protein GADD45, Ribosomal protein L7Ae/L30e/S12e/Gadd45, indicating that the gene product:
  • participates in the following biological processes:
    • response to stress

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gadd45a indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • cell cycle arrest
    • response to DNA damage stimulus

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References

1. Kamileri I et al. (2012) Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A, 109:2995-3000. (PubMed:22323595)
2. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell, 5:420-33. (PubMed:19796622)
3. Vairapandi M et al. (2002) GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. J Cell Physiol, 192:327-38. (PubMed:12124778)
4. Wang X et al. (2004) Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. J Biol Chem, 279:29606-14. (PubMed:15123655)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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