Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Abr. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of November 1, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Abr
  • performs the following molecular functions:
    • Rac GTPase activator activity ^[1]
  • is located in the following cellular components:
    • cytosol ^[1]
    • plasma membrane ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Abr
  • participates in the following biological processes:
    • negative regulation of inflammatory response ^[2]
    • response to lipopolysaccharide ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Abr
  • participates in the following biological processes:
    • actin cytoskeleton organization based on interactions with Bcr ^[1]
    • brain development based on interactions with Bcr ^[3]
    • inner ear morphogenesis based on interactions with Bcr ^[4]
    • negative regulation of cell migration based on interactions with Bcr ^[1]
    • negative regulation of neutrophil degranulation based on interactions with Bcr ^[2]
    • neuromuscular process controlling balance based on interactions with Bcr ^[4]
    • positive regulation of phagocytosis based on interactions with Bcr ^[1]
  • performs the following molecular functions:
    • Rac GTPase activator activity based on interactions with Bcr ^[2]

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Summary text based on GO annotations supported by structural data

• Abr encodes a protein or proteins that contain the following InterPro domains: C2 calcium-dependent membrane targeting, C2 calcium/lipid-binding domain, CaLB, C2 membrane targeting protein, Dbl homology (DH) domain, Guanine-nucleotide dissociation stimulator, CDC24, conserved site, Pleckstrin homology domain, Pleckstrin homology-like domain, Rho GTPase activation protein, Rho GTPase-activating protein domain, indicating that the gene product:
  • participates in the following biological processes:
    • intracellular signal transduction
    • regulation of Rho protein signal transduction
    • signal transduction
  • performs the following molecular functions:
    • guanyl-nucleotide exchange factor activity
    • phospholipid binding
    • Rho guanyl-nucleotide exchange factor activity
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Abr indicates that it:
  • performs the following molecular functions:
    • guanyl-nucleotide exchange factor activity

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References

1. Cho YJ et al. (2007) Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages. Mol Cell Biol, 27:899-911. (PubMed:17116687)
2. Cunnick JM et al. (2009) Bcr and Abr cooperate in negatively regulating acute inflammatory responses. Mol Cell Biol, 29:5742-50. (PubMed:19703997)
3. Kaartinen V et al. (2001) Abnormal function of astroglia lacking Abr and Bcr RacGAPs. Development, 128:4217-27. (PubMed:11684658)
4. Kaartinen V et al. (2002) Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs. Dev Dyn, 223:517-25. (PubMed:11921339)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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