Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Stra6. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Stra6:
  • participates in the following biological processes:
    • adrenal gland development
    • alveolar primary septum development
    • artery morphogenesis
    • blood vessel development
    • cognition
    • developmental growth
    • diaphragm development
    • digestive tract morphogenesis
    • ear development
    • embryonic camera-type eye formation
    • embryonic digestive tract development
    • eyelid development in camera-type eye
    • face morphogenesis
    • feeding behavior
    • female genitalia development
    • head development
    • head morphogenesis
    • heart development
    • kidney development
    • learning
    • lung alveolus development
    • lung development
    • lung vasculature development
    • neuromuscular process
    • nose morphogenesis
    • paramesonephric duct development
    • positive regulation of behavior
    • pulmonary artery morphogenesis
    • pulmonary valve morphogenesis
    • smooth muscle tissue development
    • uterus morphogenesis
    • ventricular septum development
    • vocal learning
  • is located in the following cellular components:
    • protein complex

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Summary text based on GO annotations supported by structural data

• Stra6 encodes a protein or proteins that contain the following InterPro domains: Stimulated by retinoic acid gene 6 protein, indicating that the gene product:
  • performs the following molecular functions:
    • receptor activity
    • vitamin transporter activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Stra6 indicates that it:
  • participates in the following biological processes:
    • transport
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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