Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Myo1a. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of November 7, 2006. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional skeletal muscle myosin-1 (MYH1). Unconventional myosins contain the basic domains characteristic of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with autosomal dominant deafness. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Dec 2011]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Myo1a
  • is located in the following cellular components:
    • apical plasma membrane ^[1]
    • basal plasma membrane ^[1]
    • brush border ^[2]
    • lateral plasma membrane ^[1]
    • microvillus ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Myo1a
  • participates in the following biological processes:
    • cell projection organization ^[2]
    • microvillus assembly ^[2]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Myo1a:
  • participates in the following biological processes:
    • regulation of protein localization
    • sensory perception of sound
    • vesicle localization
  • is located in the following cellular components:
    • actin cytoskeleton
    • basolateral plasma membrane
    • brush border
    • cell leading edge
    • cortical actin cytoskeleton
    • cytoplasm
    • filamentous actin
    • growth cone
    • lateral plasma membrane
    • membrane raft
    • microvillus
    • neuron projection
    • neuronal cell body

---

Summary text based on GO annotations supported by structural data

• Myo1a encodes a protein or proteins that contain the following InterPro domains: IQ motif, EF-hand binding site, Myosin head, motor domain, Myosin tail 2, indicating that the gene product:
  • performs the following molecular functions:
    • ATP binding
    • motor activity
  • is located in the following cellular components:
    • myosin complex

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Myo1a indicates that it:
  • performs the following molecular functions:
    • actin binding
    • ATP binding
    • calmodulin binding
    • nucleotide binding
  • is located in the following cellular components:
    • myosin complex

---

References

1. Skowron JF et al. (1999) Cloning and characterization of mouse brush border myosin-I in adult and embryonic intestine. J Exp Zool, 283:242-57. (PubMed:9933937)
2. Tyska MJ et al. (2005) Myosin-1a is critical for normal brush border structure and composition. Mol Biol Cell, 16:2443-57. (PubMed:15758024)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---