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Gene Ontology Classifications
Symbol
Name
ID
Slc5a1
solute carrier family 5 (sodium/glucose cotransporter), member 1
MGI:107678

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GO curators for mouse genes have assigned the following annotations to the gene product of Slc5a1. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Mehus JG et al. (1999) Mus musculus nucleoside diphosphate kinase (DR-nm23) mRNA, complete cds GenBank Submission, null:AF153449.
  2. Osswald C et al. (2005) Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity. Mol Cell Biol, 25:78-87. (PubMed:15601832)
  3. Wiley LM et al. (1991) Antibodies to a renal Na+/glucose cotransport system localize to the apical plasma membrane domain of polar mouse embryo blastomeres. Dev Biol, 143:149-61. (PubMed:1702069)
  4. Yang Q et al. (2000) Expression characteristics and relevance of sodium glucose cotransporter-1 in mammalian renal tubulogenesis. Am J Physiol Renal Physiol, 279:F765-77. (PubMed:10997927)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory