Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc5a1. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc5a1
  • participates in the following biological processes:
    • intestinal absorption ^[2]
  • is located in the following cellular components:
    • apical plasma membrane ^[3]
    • brush border ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Slc5a1
  • participates in the following biological processes:
    • glucose transport ^[4]
    • hexose transmembrane transport ^[4]
    • metanephros development ^[1]
  • performs the following molecular functions:
    • glucose transmembrane transporter activity ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc5a1:
  • participates in the following biological processes:
    • glucose transport
    • sodium ion transmembrane transport
  • performs the following molecular functions:
    • glucose:sodium symporter activity
  • is located in the following cellular components:
    • apical plasma membrane
    • brush border membrane
    • cell-cell junction
    • extracellular vesicular exosome

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Summary text based on GO annotations supported by structural data

• Slc5a1 encodes a protein or proteins that contain the following InterPro domains: Sodium/solute symporter, Sodium/solute symporter, conserved site, Sodium/solute symporter, subgroup, indicating that the gene product:
  • participates in the following biological processes:
    • transmembrane transport
    • transport
  • performs the following molecular functions:
    • transporter activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc5a1 indicates that it:
  • participates in the following biological processes:
    • carbohydrate transport
    • ion transport
    • sodium ion transport
    • transport
  • performs the following molecular functions:
    • symporter activity
  • is located in the following cellular components:
    • integral component of membrane
    • membrane

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References

1. Mehus JG et al. (1999) Mus musculus nucleoside diphosphate kinase (DR-nm23) mRNA, complete cds GenBank Submission, null:AF153449.
2. Osswald C et al. (2005) Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity. Mol Cell Biol, 25:78-87. (PubMed:15601832)
3. Wiley LM et al. (1991) Antibodies to a renal Na+/glucose cotransport system localize to the apical plasma membrane domain of polar mouse embryo blastomeres. Dev Biol, 143:149-61. (PubMed:1702069)
4. Yang Q et al. (2000) Expression characteristics and relevance of sodium glucose cotransporter-1 in mammalian renal tubulogenesis. Am J Physiol Renal Physiol, 279:F765-77. (PubMed:10997927)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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