Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gpm6a. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Gpm6a
  • participates in the following biological processes:
    • neural retina development ^[2]
    • neuron projection morphogenesis ^[2]
  • is located in the following cellular components:
    • axonal growth cone ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gpm6a:
  • participates in the following biological processes:
    • calcium ion transmembrane transport
    • neuron migration
    • positive regulation of filopodium assembly
    • stem cell differentiation
    • synapse assembly
  • performs the following molecular functions:
    • calcium channel activity
  • is located in the following cellular components:
    • cell surface
    • filopodium
    • neuron projection
    • neuronal cell body
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Gpm6a encodes a protein or proteins that contain the following InterPro domains: Myelin proteolipid protein PLP, Myelin proteolipid protein PLP, conserved site, indicating that the gene product:
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gpm6a indicates that it:
  • participates in the following biological processes:
    • nervous system development
  • is located in the following cellular components:
    • cell projection
    • integral to membrane
    • membrane

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References

1. Sato Y et al. (2011) Induction of axon growth arrest without growth cone collapse through the N-terminal region of four-transmembrane glycoprotein M6a. Dev Neurobiol, 71:733-46. (PubMed:21714103)
2. Zhao J et al. (2008) M6a is expressed in the murine neural retina and regulates neurite extension. Mol Vis, 14:1623-30. (PubMed:18776950)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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