Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Scn9a. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Scn9a
  • participates in the following biological processes:
    • response to toxin ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Scn9a
  • participates in the following biological processes:
    • behavioral response to pain ^[1]
    • inflammatory response ^[1]
    • post-embryonic development ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Scn9a:
  • participates in the following biological processes:
    • regulation of action potential in neuron
    • sodium ion transmembrane transport
  • performs the following molecular functions:
    • sodium ion binding
    • voltage-gated sodium channel activity
  • is located in the following cellular components:
    • voltage-gated sodium channel complex

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Summary text based on GO annotations supported by structural data

• Scn9a encodes a protein or proteins that contain the following InterPro domains: Domain of unknown function DUF3451, Ion transport domain, IQ motif, EF-hand binding site, Sodium ion transport-associated, Voltage gated sodium channel, alpha subunit, indicating that the gene product:
  • participates in the following biological processes:
    • ion transmembrane transport
    • ion transport
    • sodium ion transport
    • transmembrane transport
  • performs the following molecular functions:
    • ion channel activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Scn9a indicates that it:
  • participates in the following biological processes:
    • ion transmembrane transport
    • ion transport
    • regulation of ion transmembrane transport
    • sodium ion transmembrane transport
    • sodium ion transport
    • transport
  • performs the following molecular functions:
    • ion channel activity
    • sodium channel activity
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Nassar MA et al. (2004) Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci U S A, 101:12706-11. (PubMed:15314237)
2. Rush AM et al. (2005) Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur J Neurosci, 22:39-49. (PubMed:16029194)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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