Automated description from the Alliance of Genome Resources (Release 4.0)
Predicted to have GTPase activity. Involved in several processes, including cellular response to interferon-gamma; positive regulation of autophagosome maturation; and positive regulation of interferon-gamma-mediated signaling pathway. Localizes to autolysosome; late endosome; and phagocytic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M).