Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Irgm1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Irgm1
  • is located in the following cellular components:
    • late endosome ^[2]
    • lysosome ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Irgm1
  • participates in the following biological processes:
    • defense response ^[1]

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Summary text based on GO annotations supported by structural data

• Irgm1 encodes a protein or proteins that contain the following InterPro domains: Interferon-inducible GTPase, indicating that the gene product:
  • performs the following molecular functions:
    • GTP binding
    • hydrolase activity, acting on acid anhydrides
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Irgm1 indicates that it:
  • participates in the following biological processes:
    • autophagy
    • innate immune response
  • performs the following molecular functions:
    • GTP binding
    • hydrolase activity
    • nucleotide binding
  • is located in the following cellular components:
    • cell projection
    • cytoplasmic vesicle
    • endosome
    • Golgi apparatus
    • membrane
    • plasma membrane

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References

1. Collazo CM et al. (2001) Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J Exp Med, 194:181-8. (PubMed:11457893)
2. Zhao YO et al. (2010) Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells. PLoS One, 5:e8648. (PubMed:20072621)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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