Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables GTPase activity and anion binding activity. Involved in several processes, including macroautophagy; positive regulation of macroautophagy; and regulation of defense response. Acts upstream of or within cellular response to type II interferon and response to bacterium. Located in autolysosome; late endosome; and phagocytic vesicle. Is active in Golgi membrane; lysosomal membrane; and mitochondrial membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M).