Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in gene expression; heart contraction; and sinoatrial node development. Acts upstream of or within several processes, including cardiac muscle hypertrophy in response to stress; endodermal cell fate determination; and epithelial cell differentiation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and heart. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); congenital heart disease (multiple); and pancreatic hypoplasia-diabetes-congenital heart disease syndrome. Orthologous to human GATA6 (GATA binding protein 6).