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Gene Ontology Classifications
GATA binding protein 6

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gata6. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Alexandrovich A et al. (2006) Wnt2 is a direct downstream target of GATA6 during early cardiogenesis. Mech Dev, 123:297-311. (PubMed:16621466)
  2. Bosse T et al. (2006) Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. Mol Cell Biol, 26:9060-70. (PubMed:16940177)
  3. Brewer AC et al. (2005) GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis. Stem Cells Dev, 14:425-39. (PubMed:16137232)
  4. Crawford SE et al. (2002) Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. J Biol Chem, 277:3585-92. (PubMed:11724781)
  5. Decker K et al. (2006) Gata6 is an important regulator of mouse pancreas development. Dev Biol, 298:415-29. (PubMed:16887115)
  6. Di Lisi R et al. (1998) Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo. J Biol Chem, 273:25371-80. (PubMed:9738004)
  7. Heikinheimo M et al. (1997) Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary. Endocrinology, 138:3505-14. (PubMed:9231805)
  8. Karamboulas K et al. (2010) Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals. J Cell Sci, 123:2068-76. (PubMed:20501701)
  9. Kiiveri S et al. (2002) Differential expression of GATA-4 and GATA-6 in fetal and adult mouse and human adrenal tissue. Endocrinology, 143:3136-43. (PubMed:12130579)
  10. Kyrmizi I et al. (2006) Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev, 20:2293-305. (PubMed:16912278)
  11. Liu C et al. (2002) GATA-6 and Thyroid Transcription Factor-1 Directly Interact and Regulate Surfactant Protein-C Gene Expression. J Biol Chem, 277:4519-25. (PubMed:11733512)
  12. Maitra M et al. (2009) Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev Biol, 326:368-77. (PubMed:19084512)
  13. Morris SA et al. (2010) Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo. Proc Natl Acad Sci U S A, 107:6364-9. (PubMed:20308546)
  14. Morrisey EE et al. (1998) GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes Dev, 12:3579-90. (PubMed:9832509)
  15. Morrisey EE et al. (1996) GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev Biol, 177:309-22. (PubMed:8660897)
  16. Niakan KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev, 24:312-26. (PubMed:20123909)
  17. Rath N et al. (2005) LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding. Mol Cell Biol, 25:8864-73. (PubMed:16199866)
  18. Ritz-Laser B et al. (2005) The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression. Mol Endocrinol, 19:759-70. (PubMed:15539431)
  19. Rojas A et al. (2005) Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element. Development, 132:3405-17. (PubMed:15987774)
  20. Shirvani S et al. (2006) CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6. Biochem Biophys Res Commun, 339:151-6. (PubMed:16293227)
  21. Tian Y et al. (2011) Regulation of lung endoderm progenitor cell behavior by miR302/367. Development, 138:1235-45. (PubMed:21350014)
  22. van Berlo JH et al. (2010) The transcription factor GATA-6 regulates pathological cardiac hypertrophy. Circ Res, 107:1032-40. (PubMed:20705924)
  23. Weidenfeld J et al. (2002) The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J Biol Chem, 277:21061-70. (PubMed:11914369)
  24. Yin Z et al. (2006) Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. Am J Physiol Lung Cell Mol Physiol, 291:L191-9. (PubMed:16510470)
  25. Zhang K et al. (2013) CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Dev Biol, 383:15-27. (PubMed:24036311)
  26. Zhang Y et al. (2007) GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo. Development, 134:189-98. (PubMed:17164424)
  27. Zhao R et al. (2005) GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol, 25:2622-31. (PubMed:15767668)
  28. Zhao R et al. (2008) Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev Biol, 317:614-9. (PubMed:18400219)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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