Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II repressing transcription factor binding activity. Involved in several processes, including animal organ development; cardiac muscle hypertrophy in response to stress; and endodermal cell fate determination. Localizes to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma and congenital heart disease (multiple). Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and heart. Orthologous to human GATA6 (GATA binding protein 6).