Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Alox5ap. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 16, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Alox5ap
  • participates in the following biological processes:
    • leukotriene biosynthetic process ^[3]
  • is located in the following cellular components:
    • nucleus ^[3]
• The gene product of Alox5ap has been shown to bind to the gene products of Alox5. ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Alox5ap
  • participates in the following biological processes:
    • leukotriene biosynthetic process ^[1]
    • leukotriene production involved in inflammatory response ^{[1, 2]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Alox5ap:
  • participates in the following biological processes:
    • cellular response to calcium ion
    • glutathione biosynthetic process
    • leukotriene biosynthetic process
    • lipoxygenase pathway
    • oxidation-reduction process
    • positive regulation of acute inflammatory response
    • protein homotrimerization
  • performs the following molecular functions:
    • arachidonate 5-lipoxygenase activity
    • arachidonic acid binding
    • enzyme binding
    • glutathione peroxidase activity
    • glutathione transferase activity
    • protein heterodimerization activity
    • protein homodimerization activity
    • protein N-terminus binding
  • is located in the following cellular components:
    • cytosol
    • endoplasmic reticulum
    • nuclear envelope
    • nuclear membrane

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Summary text based on GO annotations supported by structural data

• Alox5ap encodes a protein or proteins that contain the following InterPro domains: 5-lipoxygenase-activating protein, FLAP/GST2/LTC4S, conserved site, Membrane associated eicosanoid/glutathione metabolism-like domain, Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein, indicating that the gene product:
  • participates in the following biological processes:
    • leukotriene metabolic process
    • positive regulation of catalytic activity
  • performs the following molecular functions:
    • enzyme activator activity
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Alox5ap indicates that it:
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Byrum RS et al. (1997) Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses. J Exp Med, 185:1065-75. (PubMed:9091580)
2. Goulet JL et al. (2000) Genetic factors determine the contribution of leukotrienes to acute inflammatory responses. J Immunol, 164:4899-907. (PubMed:10779800)
3. Mandal AK et al. (2008) The nuclear membrane organization of leukotriene synthesis. Proc Natl Acad Sci U S A, 105:20434-9. (PubMed:19075240)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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