Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables dihydrolipoyl dehydrogenase activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Acts upstream of or within several processes, including gastrulation; mitochondrial electron transport, NADH to ubiquinone; and sperm capacitation. Located in acrosomal matrix; cilium; and mitochondrion. Part of acetyltransferase complex; mitochondrial pyruvate dehydrogenase complex; and oxoglutarate dehydrogenase complex. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DLD (dihydrolipoamide dehydrogenase).