Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Efna5. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Efna5
  • participates in the following biological processes:
    • axon guidance ^[1]
    • ephrin receptor signaling pathway ^{[5, 6]}
    • negative chemotaxis ^[7]
    • positive regulation of peptidyl-tyrosine phosphorylation ^[5]
    • regulation of actin cytoskeleton organization ^[5]
    • regulation of cell-cell adhesion ^[3]
    • regulation of Rac GTPase activity ^[5]
    • retinal ganglion cell axon guidance ^[7]
  • performs the following molecular functions:
    • chemorepellent activity ^[7]
  • is located in the following cellular components:
    • plasma membrane ^[5]
• The gene product of Efna5 has been shown to bind to the gene products of Epha5. ^[2] Researchers have inferred, based on physical interactions, that the gene product of Efna5
  • performs the following molecular functions:
    • ephrin receptor binding ^{[3, 6]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Efna5
  • participates in the following biological processes:
    • axon guidance ^[4]
    • regulation of insulin secretion involved in cellular response to glucose stimulus ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Efna5:
  • participates in the following biological processes:
    • brain development
    • ephrin receptor signaling pathway
    • regulation of actin cytoskeleton organization
    • regulation of cell-cell adhesion
    • regulation of focal adhesion assembly
    • regulation of microtubule cytoskeleton organization
    • regulation of Rho GTPase activity
  • performs the following molecular functions:
    • ephrin receptor binding
  • is located in the following cellular components:
    • anchored to external side of plasma membrane

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Summary text based on GO annotations supported by structural data

• Efna5 encodes a protein or proteins that contain the following InterPro domains: Cupredoxin, Ephrin, Ephrin, conserved site, indicating that the gene product:
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Efna5 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • nervous system development
  • is located in the following cellular components:
    • anchored to membrane
    • membrane

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References

1. Castellani V et al. (1998) Dual action of a ligand for Eph receptor tyrosine kinases on specific populations of axons during the development of cortical circuits. J Neurosci, 18:4663-72. (PubMed:9614241)
2. Feldheim DA et al. (1998) Topographic guidance labels in a sensory projection to the forebrain. Neuron, 21:1303-13. (PubMed:9883724)
3. Holmberg J et al. (2000) Regulation of repulsion versus adhesion by different splice forms of an Eph receptor. Nature, 408:203-6. (PubMed:11089974)
4. Knoll B et al. (2001) A role for the EphA family in the topographic targeting of vomeronasal axons. Development, 128:895-906. (PubMed:11222144)
5. Konstantinova I et al. (2007) EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell, 129:359-70. (PubMed:17448994)
6. Park S et al. (1997) The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. Oncogene, 14:533-42. (PubMed:9053851)
7. Rashid T et al. (2005) Opposing Gradients of Ephrin-As and EphA7 in the Superior Colliculus Are Essential for Topographic Mapping in the Mammalian Visual System. Neuron, 47:57-69. (PubMed:15996548)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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