Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits calcium-dependent cysteine-type endopeptidase activity; metal ion binding activity; and molecular adaptor activity. Involved in several processes, including G1 to G0 transition involved in cell differentiation; regulation of transcription, DNA-templated; and sarcomere organization. Localizes to cytosol; plasma membrane; and protein-containing complex. Is expressed in several structures, including brain; eye; heart; and musculature. Used to study autosomal recessive limb-girdle muscular dystrophy type 2A. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; and muscular dystrophy. Orthologous to human CAPN3 (calpain 3).