Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ptprn2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ptprn2
  • is located in the following cellular components:
    • secretory granule ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ptprn2:
  • participates in the following biological processes:
    • negative regulation of GTPase activity
  • is located in the following cellular components:
    • cytoplasm
    • endoplasmic reticulum lumen
    • secretory granule
    • terminal button

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Summary text based on GO annotations supported by structural data

• Ptprn2 encodes a protein or proteins that contain the following InterPro domains: Protein-tyrosine phosphatase receptor IA-2, Protein-tyrosine phosphatase, active site, Protein-tyrosine phosphatase, receptor/non-receptor type, Protein-tyrosine/Dual-specificity phosphatase, indicating that the gene product:
  • participates in the following biological processes:
    • dephosphorylation
    • protein dephosphorylation
  • performs the following molecular functions:
    • phosphatase activity
    • protein tyrosine phosphatase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ptprn2 indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
    • phosphoprotein phosphatase activity
  • is located in the following cellular components:
    • cytoplasmic vesicle
    • integral to membrane
    • membrane
• Ptprn2 has been associated with the Enzyme Commission numbers: 3.1.3.48, which implies that the gene product:
  • performs the following molecular functions:
    • protein tyrosine phosphatase activity

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References

1. Varadi A et al. (2005) Myosin Va transports dense core secretory vesicles in pancreatic MIN6 {beta}-cells. Mol Biol Cell, 16:2670-80. (PubMed:15788565)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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