Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pitx1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Pitx1
  • participates in the following biological processes:
    • hindlimb morphogenesis ^{[4, 6]}
    • positive regulation of transcription from RNA polymerase II promoter ^[2]
  • is located in the following cellular components:
    • cytoplasm ^[8]
    • nucleus ^[8]
    • transcription factor complex ^[7]
• Researchers have inferred, based on physical interactions, that the gene product of Pitx1
  • performs the following molecular functions:
    • protein binding transcription factor activity ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Pitx1
  • participates in the following biological processes:
    • branchiomeric skeletal muscle development ^[9]
    • cartilage development ^[5]
    • hindlimb morphogenesis ^{[5, 10]}
    • myoblast cell fate commitment ^[9]
    • pituitary gland development ^[10]
    • skeletal system development ^[5]
• Researchers have inferred, based on genetic interactions, that the gene product of Pitx1
  • participates in the following biological processes:
    • embryonic hindlimb morphogenesis based on interactions with Pitx2 ^[3]
    • positive regulation of transcription from RNA polymerase II promoter based on interactions with Ldb1, Ldb2, Lhx3, Rlim ^{[1, 2]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Pitx1:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • sequence-specific DNA binding transcription factor activity
  • is located in the following cellular components:
    • nucleolus

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Summary text based on GO annotations supported by structural data

• Pitx1 encodes a protein or proteins that contain the following InterPro domains: Homeobox protein Pitx/unc30, Homeobox, conserved site, Homeodomain, Homeodomain-like, OAR domain, indicating that the gene product:
  • performs the following molecular functions:
    • DNA binding
    • sequence-specific DNA binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pitx1 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding

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References

1. Bach I et al. (1999) RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat Genet, 22:394-9. (PubMed:10431247)
2. Bach I et al. (1997) A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. Genes Dev, 11:1370-80. (PubMed:9192866)
3. De Langhe SP et al. (2008) Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by beta-catenin Signaling. PLoS ONE, 3:e1516. (PubMed:18231602)
4. DeLaurier A et al. (2006) Pitx1 determines the morphology of muscle, tendon, and bones of the hindlimb. Dev Biol, 299:22-34. (PubMed:16989801)
5. Lanctot C et al. (1999) Hindlimb patterning and mandible development require the Ptx1 gene. Development, 126:1805-10. (PubMed:10101115)
6. Minguillon C et al. (2005) Tbx5 and Tbx4 are not sufficient to determine limb-specific morphologies but have common roles in initiating limb outgrowth. Dev Cell, 8:75-84. (PubMed:15621531)
7. Potter M et al. (1997) Indomethacin is a potent inhibitor of pristane and plastic disc induced plasmacytomagenesis in a hypersusceptible BALB/c congenic strain. Blood, 90:260-9. (PubMed:9207461)
8. Sambasivan R et al. (2009) Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. Dev Cell, 16:810-21. (PubMed:19531352)
9. Shih HP et al. (2007) Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch. Proc Natl Acad Sci U S A, 104:5907-12. (PubMed:17384148)
10. Szeto DP et al. (1999) Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. Genes Dev, 13:484-94. (PubMed:10049363)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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