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Gene Ontology Classifications
Symbol
Name
ID
Stxbp1
syntaxin binding protein 1
MGI:107363

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Stxbp1. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Bouwman J et al. (2004) Quantification of synapse formation and maintenance in vivo in the absence of synaptic release. Neuroscience, 126:115-26. (PubMed:15145078)
  2. Fukuda M. (2003) Slp4-a/Granuphilin-a Inhibits Dense-core Vesicle Exocytosis through Interaction with the GDP-bound Form of Rab27A in PC12 Cells. J Biol Chem, 278:15390-6. (PubMed:12590134)
  3. Heeroma JH et al. (2004) Trophic support delays but does not prevent cell-intrinsic degeneration of neurons deficient for munc18-1. Eur J Neurosci, 20:623-34. (PubMed:15255974)
  4. Ho A et al. (2006) Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. J Neurosci, 26:13089-101. (PubMed:17167098)
  5. Katagiri H et al. (1995) A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. J Biol Chem, 270:4963-6. (PubMed:7890599)
  6. Korteweg N et al. (2004) Development of the mouse hypothalamo-neurohypophysial system in the munc18-1 null mutant that lacks regulated secretion. Eur J Neurosci, 19:2944-52. (PubMed:15182301)
  7. Lilja L et al. (2004) Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis. J Biol Chem, 279:29534-41. (PubMed:15123626)
  8. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
  9. Toonen RF et al. (2006) Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size. Proc Natl Acad Sci U S A, 103:18332-7. (PubMed:17110441)
  10. Voets T et al. (2001) Munc18-1 promotes large dense-core vesicle docking. Neuron, 31:581-91. (PubMed:11545717)
  11. Wentzel C et al. (2013) mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking. Neuron, 78:1012-23. (PubMed:23791195)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory