Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ctse. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ctse
  • participates in the following biological processes:
    • antigen processing and presentation of exogenous peptide antigen via MHC class II ^[2]
    • metabolic process ^[3]
  • performs the following molecular functions:
    • aspartic-type endopeptidase activity ^[3]
    • protein homodimerization activity ^[4]
  • is located in the following cellular components:
    • endosome ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ctse:
  • participates in the following biological processes:
    • antigen processing and presentation of exogenous peptide antigen via MHC class II
    • protein autoprocessing
  • performs the following molecular functions:
    • aspartic-type endopeptidase activity
  • is located in the following cellular components:
    • endosome

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Summary text based on GO annotations supported by structural data

• Ctse encodes a protein or proteins that contain the following InterPro domains: Peptidase A1, Peptidase aspartic, Peptidase aspartic, active site, Peptidase aspartic, catalytic, Propeptide, peptidase A1, indicating that the gene product:
  • participates in the following biological processes:
    • proteolysis

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ctse indicates that it:
  • participates in the following biological processes:
    • proteolysis
  • performs the following molecular functions:
    • hydrolase activity
    • peptidase activity

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References

1. Bennett K et al. (1992) Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E. Eur J Immunol, 22:1519-24. (PubMed:1601038)
2. Nishioku T et al. (2002) Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia. J Biol Chem, 277:4816-22. (PubMed:11719510)
3. Tatnell PJ et al. (1997) Cloning, expression and characterisation of murine procathepsin E. FEBS Lett, 408:62-6. (PubMed:9180269)
4. Yee CS et al. (2004) Cathepsin E: a novel target for regulation by class II transactivator. J Immunol, 172:5528-34. (PubMed:15100295)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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