Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Inpp5d. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Inpp5d
  • participates in the following biological processes:
    • dephosphorylation ^{[1, 5]}
    • negative regulation of cell proliferation ^[5]
  • performs the following molecular functions:
    • inositol-polyphosphate 5-phosphatase activity ^[1]
    • phosphatidylinositol trisphosphate phosphatase activity ^[5]
    • PTB domain binding ^[6]
    • SH3 domain binding ^[1]
• The gene product of Inpp5d has been shown to bind to the gene products of Cd300a, Gm885, Nup62, Plcg2. ^{[4, 7, 8, 9, 11]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Inpp5d
  • participates in the following biological processes:
    • determination of adult lifespan ^[2]
    • immunoglobulin mediated immune response ^[3]
    • intracellular signal transduction ^[3]
    • negative regulation of B cell activation ^[3]
    • negative regulation of B cell proliferation ^[3]
    • negative regulation of bone resorption ^[10]
    • negative regulation of granulocyte differentiation ^[2]
    • negative regulation of immune response ^[3]
    • negative regulation of interleukin-6 biosynthetic process ^[10]
    • negative regulation of monocyte differentiation ^[2]
    • negative regulation of neutrophil differentiation ^[2]
    • negative regulation of osteoclast differentiation ^[10]
    • negative regulation of signal transduction ^{[2, 3, 10]}
    • positive regulation of apoptotic process ^[10]
    • positive regulation of B cell differentiation ^{[2, 3]}
    • positive regulation of erythrocyte differentiation ^[2]
    • positive regulation of lymphocyte differentiation ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Inpp5d:
  • performs the following molecular functions:
    • inositol-4,5-bisphosphate 5-phosphatase activity
  • is located in the following cellular components:
    • actin filament
    • cortical cytoskeleton
    • cytosol
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Inpp5d encodes a protein or proteins that contain the following InterPro domains: Endonuclease/exonuclease/phosphatase, Inositol polyphosphate-related phosphatase, SH2 domain, indicating that the gene product:
  • participates in the following biological processes:
    • phosphatidylinositol phosphorylation

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Inpp5d indicates that it:
  • participates in the following biological processes:
    • apoptotic process
  • performs the following molecular functions:
    • hydrolase activity
  • is located in the following cellular components:
    • cytoplasm
    • membrane

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References

1. Damen JE et al. (1996) The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A, 93:1689-93. (PubMed:8643691)
2. Helgason CD et al. (1998) Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. Genes Dev, 12:1610-20. (PubMed:9620849)
3. Helgason CD et al. (2000) A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice. J Exp Med, 191:781-94. (PubMed:10704460)
4. Hitomi K et al. (2010) An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. Nat Immunol, 11:601-7. (PubMed:20526344)
5. Kang AD et al. (1996) Restoration of lipopolysaccharide-mediated B-cell response after expression of a cDNA encoding a GTP-binding protein. Infect Immun, 64:4612-7. (PubMed:8890215)
6. Lioubin MN et al. (1996) p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. Genes Dev, 10:1084-95. (PubMed:8654924)
7. Lucas DM et al. (1999) A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development. Blood, 93:1922-33. (PubMed:10068665)
8. Papin J et al. (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol, 15:78-81. (PubMed:15102471)
9. Sattler M et al. (2001) SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL. J Biol Chem, 276:2451-8. (PubMed:11031258)
10. Takeshita S et al. (2002) SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat Med, 8:943-9. (PubMed:12161749)
11. Yotsumoto K et al. (2003) Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. J Exp Med, 198:223-33. (PubMed:12874256)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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