Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gpr143. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Gpr143
  • participates in the following biological processes:
    • melanosome localization ^[1]
    • melanosome organization ^[1]
    • melanosome transport ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gpr143:
  • participates in the following biological processes:
    • calcium-mediated signaling using intracellular calcium source
    • G-protein coupled receptor signaling pathway
    • melanosome localization
    • melanosome organization
    • melanosome transport
    • neuropeptide signaling pathway
    • phosphatidylinositol-mediated signaling
    • regulation of calcium-mediated signaling
    • synaptic transmission
  • performs the following molecular functions:
    • dopamine binding
    • G-protein coupled receptor activity
    • L-DOPA binding
    • L-DOPA receptor activity
    • tyrosine binding
  • is located in the following cellular components:
    • apical plasma membrane
    • Golgi apparatus
    • lysosomal membrane
    • melanosome
    • melanosome membrane
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Gpr143 encodes a protein or proteins that contain the following InterPro domains: Ocular albinism protein, type 1, indicating that the gene product:
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gpr143 indicates that it:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • lysosome
    • membrane

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References

1. Palmisano I et al. (2008) The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells. Hum Mol Genet, 17:3487-501. (PubMed:18697795)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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