Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including hemopoiesis; negative regulation of signal transduction; and regulation of lymphocyte activation. Localizes to nucleus. Predicted to colocalize with replication fork. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in B-cell lymphoma and diffuse large B-cell lymphoma. Orthologous to human BCL6 (BCL6 transcription repressor).