Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Serpinf2. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Serpinf2
  • participates in the following biological processes:
    • blood vessel morphogenesis ^[1]
    • collagen fibril organization ^[2]
    • positive regulation of cell differentiation ^[3]
    • positive regulation of collagen biosynthetic process ^[1]
    • positive regulation of smooth muscle cell proliferation ^[1]
    • positive regulation of transcription from RNA polymerase II promoter ^[2]
    • positive regulation of transforming growth factor beta production ^[2]
    • regulation of blood vessel size by renin-angiotensin ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Serpinf2:
  • participates in the following biological processes:
    • negative regulation of endopeptidase activity
    • negative regulation of fibrinolysis
    • negative regulation of plasminogen activation
    • positive regulation of cell differentiation
    • positive regulation of collagen biosynthetic process
    • positive regulation of ERK1 and ERK2 cascade
    • positive regulation of JNK cascade
    • positive regulation of stress fiber assembly
    • positive regulation of transcription from RNA polymerase II promoter
    • positive regulation of transforming growth factor beta production
    • regulation of proteolysis
  • performs the following molecular functions:
    • protease binding
    • protein homodimerization activity
    • serine-type endopeptidase inhibitor activity
  • is located in the following cellular components:
    • blood microparticle
    • cell surface
    • extracellular space
    • extracellular vesicular exosome
    • fibrinogen complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Serpinf2 indicates that it:
  • participates in the following biological processes:
    • acute-phase response
    • negative regulation of peptidase activity
  • performs the following molecular functions:
    • peptidase inhibitor activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Hou Y et al. (2008) Alpha2-antiplasmin is a critical regulator of angiotensin II-mediated vascular remodeling. Arterioscler Thromb Vasc Biol, 28:1257-62. (PubMed:18436805)
2. Kanno Y et al. (2007) Alpha2-antiplasmin is involved in the production of transforming growth factor beta1 and fibrosis. J Thromb Haemost, 5:2266-73. (PubMed:17958745)
3. Kanno Y et al. (2010) alpha2-antiplasmin is associated with the progression of fibrosis. Am J Pathol, 176:238-45. (PubMed:20008146)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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