Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including calcineurin-NFAT signaling cascade; regulation of RNA metabolic process; and regulation of muscle adaptation. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; Z disc; and calcineurin complex. Predicted to colocalize with cytoplasmic side of plasma membrane and slit diaphragm. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; gut gland; and jaw. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in infantile or early childhood epileptic encephalopathy 1. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha).