Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tmpo. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Tmpo
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent ^[2]
  • is located in the following cellular components:
    • nuclear envelope ^{[1, 2]}
• The gene product of Tmpo has been shown to bind to the gene products of Gmcl1, Zbtb7b. ^{[2, 3]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tmpo:
  • is located in the following cellular components:
    • chromatin
    • nuclear inner membrane
    • nucleus

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Summary text based on GO annotations supported by structural data

• Tmpo encodes a protein or proteins that contain the following InterPro domains: Lamina-associated polypeptide 2 alpha, Lamino-associated polypeptide 2/emerin, LEM-like domain, Thymopoietin LEM, indicating that the gene product:
  • performs the following molecular functions:
    • DNA binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tmpo indicates that it:
  • performs the following molecular functions:
    • DNA binding
  • is located in the following cellular components:
    • chromosome
    • integral to membrane
    • membrane

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References

1. Hebbar S et al. (2008) Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells. J Cell Biol, 182:1063-71. (PubMed:18809722)
2. Nili E et al. (2001) Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J Cell Sci, 114:3297-307. (PubMed:11591818)
3. Zullo JM et al. (2012) DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina. Cell, 149:1474-87. (PubMed:22726435)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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