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Gene Ontology Classifications
zinc finger protein of the cerebellum 2

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GO curators for mouse genes have assigned the following annotations to the gene product of Zic2. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Aruga J et al. (2002) Zic2 controls cerebellar development in cooperation with zic1. J Neurosci, 22:218-25. (PubMed:11756505)
  2. Barratt KS et al. (2014) The Zic2 gene directs the formation and function of node cilia to control cardiac situs. Genesis, 52:626-35. (PubMed:24585447)
  3. Bogani D et al. (2004) New semidominant mutations that affect mouse development. Genesis, 40:109. (PubMed:15384171)
  4. Brown L et al. (2009) Zic2 is expressed in pluripotent cells in the blastocyst and adult brain expression overlaps with makers of neurogenesis. Gene Expr Patterns, 9:43-9. (PubMed:18755297)
  5. Brown LY et al. (2003) Immunolocalization of Zic2 expression in the developing mouse forebrain. Gene Expr Patterns, 3:361-7. (PubMed:12799086)
  6. Garcia-Frigola C et al. (2010) Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets. EMBO J, 29:3170-83. (PubMed:20676059)
  7. Herrera E et al. (2003) Zic2 patterns binocular vision by specifying the uncrossed retinal projection. Cell, 114:545-57. (PubMed:13678579)
  8. Ishiguro A et al. (2008) Functional role of Zic2 phosphorylation in transcriptional regulation. FEBS Lett, 582:154-8. (PubMed:18068128)
  9. Ishiguro A et al. (2004) Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family. Biochem Biophys Res Commun, 324:302-7. (PubMed:15465018)
  10. Koyabu Y et al. (2001) Physical and functional interactions between Zic and Gli proteins. J Biol Chem, 276:6889-92. (PubMed:11238441)
  11. Mizugishi K et al. (2004) Myogenic repressor I-mfa interferes with the function of Zic family proteins. Biochem Biophys Res Commun, 320:233-40. (PubMed:15207726)
  12. Mizugishi K et al. (2001) Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J Biol Chem, 276:2180-8. (PubMed:11053430)
  13. Nagai T et al. (2000) Zic2 regulates the kinetics of neurulation. Proc Natl Acad Sci U S A, 97:1618-23. (PubMed:10677508)
  14. Nolan PM et al. (2000) A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet, 25:440-3. (PubMed:10932191)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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