Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Zic2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Zic2
  • participates in the following biological processes:
    • negative regulation of transcription, DNA-dependent ^[10]
    • positive regulation of sequence-specific DNA binding transcription factor activity ^[4]
    • positive regulation of transcription, DNA-dependent ^{[4, 7]}
  • performs the following molecular functions:
    • chromatin DNA binding ^[4]
    • DNA binding ^{[6, 7]}
    • sequence-specific DNA binding transcription factor activity ^{[7, 10]}
  • is located in the following cellular components:
    • cytoplasm ^{[7, 9]}
    • nucleus ^{[3, 6, 7, 8, 9]}
• The gene product of Zic2 has been shown to bind to the gene products of Dhx9, Mdfic. ^{[6, 7, 8, 9]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Zic2
  • participates in the following biological processes:
    • cell differentiation ^[2]
    • developmental pigmentation ^[12]
    • nervous system development ^[11]
    • neural tube closure ^[2]
    • retinal ganglion cell axon guidance ^[5]
    • visual perception ^{[4, 5]}
• Researchers have inferred, based on genetic interactions, that the gene product of Zic2
  • participates in the following biological processes:
    • central nervous system development based on interactions with Zic1 ^[1]

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Summary text based on GO annotations supported by structural data

• Zic2 encodes a protein or proteins that contain the following InterPro domains: Zinc finger C2H2-type/integrase DNA-binding domain, Zinc finger, C2H2, Zinc finger, C2H2-like, indicating that the gene product:
  • performs the following molecular functions:
    • nucleic acid binding
    • zinc ion binding
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Zic2 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • metal ion binding

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References

1. Aruga J et al. (2002) Zic2 controls cerebellar development in cooperation with zic1. J Neurosci, 22:218-25. (PubMed:11756505)
2. Bogani D et al. (2004) New semidominant mutations that affect mouse development. Genesis, 40:109. (PubMed:15384171)
3. Brown LY et al. (2003) Immunolocalization of Zic2 expression in the developing mouse forebrain. Gene Expr Patterns, 3:361-7. (PubMed:12799086)
4. Garcia-Frigola C et al. (2010) Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets. EMBO J, 29:3170-83. (PubMed:20676059)
5. Herrera E et al. (2003) Zic2 patterns binocular vision by specifying the uncrossed retinal projection. Cell, 114:545-57. (PubMed:13678579)
6. Ishiguro A et al. (2008) Functional role of Zic2 phosphorylation in transcriptional regulation. FEBS Lett, 582:154-8. (PubMed:18068128)
7. Ishiguro A et al. (2004) Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family. Biochem Biophys Res Commun, 324:302-7. (PubMed:15465018)
8. Koyabu Y et al. (2001) Physical and functional interactions between Zic and Gli proteins. J Biol Chem, 276:6889-92. (PubMed:11238441)
9. Mizugishi K et al. (2004) Myogenic repressor I-mfa interferes with the function of Zic family proteins. Biochem Biophys Res Commun, 320:233-40. (PubMed:15207726)
10. Mizugishi K et al. (2001) Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J Biol Chem, 276:2180-8. (PubMed:11053430)
11. Nagai T et al. (2000) Zic2 regulates the kinetics of neurulation. Proc Natl Acad Sci U S A, 97:1618-23. (PubMed:10677508)
12. Nolan PM et al. (2000) A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet, 25:440-3. (PubMed:10932191)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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