Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 9.0.0)

Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including axis specification; mRNA transcription by RNA polymerase II; and nervous system development. Acts upstream of or within anterior/posterior pattern specification; heart looping; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; egg cylinder; embryo mesenchyme; genitourinary system; and visual system. Used to study Goldenhar syndrome and visceral heterotaxy. Human ortholog(s) of this gene implicated in X-linked VACTERL association; visceral heterotaxy 1; and visceral heterotaxy 5. Orthologous to human ZIC3 (Zic family zinc finger 3).

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Gene Ontology Evidence Code Abbreviations:

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