Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits methylenetetrahydrofolate reductase (NAD(P)H) activity. Involved in methionine biosynthetic process. Predicted to localize to cytosol and synapse. Is expressed in several structures, including central nervous system; cranium; heart; sensory organ; and testis. Used to study neural tube defect. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); eye disease (multiple); hematologic cancer (multiple); and kidney failure (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase).