Automated description from the Alliance of Genome Resources
Exhibits methylenetetrahydrofolate reductase (NAD(P)H) activity. Involved in methionine biosynthetic process. Predicted to localize to the cytosol and synapse. Used to study neural tube defect. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); eye disease (multiple); hematologic cancer (multiple); and kidney failure (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase).