Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dvl2. (This text reflects annotations as of Tuesday, July 8, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Dvl2
  • participates in the following biological processes:
    • canonical Wnt signaling pathway ^[]
    • cellular protein localization ^[]
    • positive regulation of JUN kinase activity ^[]
    • Wnt signaling pathway ^[]
  • performs the following molecular functions:
    • protein self-association ^[]
  • is located in the following cellular components:
    • apical part of cell ^[]
    • clathrin-coated vesicle ^[]
    • cytoplasm ^{[, , ]}
    • cytosol ^[]
    • plasma membrane ^{[, , , ]}
• Researchers have inferred, based on physical interactions, that the gene product of Dvl2
  • performs the following molecular functions:
    • frizzled binding ^[]
    • identical protein binding ^[]
    • protein domain specific binding ^[]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Dvl2
  • participates in the following biological processes:
    • canonical Wnt signaling pathway ^[]
    • convergent extension involved in neural plate elongation ^[]
    • heart development ^{[, ]}
    • neural tube closure ^[]
    • outflow tract morphogenesis ^[]
    • planar cell polarity pathway involved in neural tube closure ^[]
    • positive regulation of canonical Wnt signaling pathway ^[]
    • segment specification ^[]
  • is located in the following cellular components:
    • nucleus ^[]
• Researchers have inferred, based on genetic interactions, that the gene product of Dvl2
  • participates in the following biological processes:
    • canonical Wnt signaling pathway based on interactions with Csnk1e, Wnt3a ^{[, ]}
    • cochlea morphogenesis based on interactions with Dvl1, Dvl3 ^{[, ]}
    • convergent extension involved in neural plate elongation based on interactions with Dvl1, Vangl2 ^[]
    • convergent extension involved in organogenesis based on interactions with Dvl1 ^[]
    • heart morphogenesis based on interactions with Dvl3 ^[]
    • planar cell polarity pathway involved in neural tube closure based on interactions with Dvl1, Vangl2 ^[]
    • positive regulation of protein tyrosine kinase activity based on interactions with Wnt3a ^[]
    • segmentation based on interactions with ^[]
    • Wnt signaling pathway, planar cell polarity pathway based on interactions with Dvl1 ^[]
  • is located in the following cellular components:
    • plasma membrane based on interactions with Wnt3a ^[]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Dvl2:
  • participates in the following biological processes:
    • canonical Wnt signaling pathway
    • canonical Wnt signaling pathway involved in regulation of cell proliferation
    • cell migration in hindbrain
    • non-canonical Wnt signaling pathway
    • positive regulation of JUN kinase activity
    • positive regulation of protein phosphorylation
    • positive regulation of sequence-specific DNA binding transcription factor activity
    • positive regulation of transcription, DNA-templated
    • regulation of JNK cascade
    • transcription from RNA polymerase II promoter
    • Wnt signaling pathway
    • Wnt signaling pathway, planar cell polarity pathway
  • performs the following molecular functions:
    • frizzled binding
    • identical protein binding
  • is located in the following cellular components:
    • cell cortex
    • cytoplasm
    • cytoplasmic vesicle

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Summary text based on GO annotations supported by structural data

• Dvl2 encodes a protein or proteins that contain the following InterPro domains: indicating that the gene product:
  • participates in the following biological processes:
    • intracellular signal transduction
    • multicellular organismal development
  • performs the following molecular functions:
    • signal transducer activity
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Dvl2 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
  • is located in the following cellular components:
    • membrane

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References

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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