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Gene Ontology Classifications
dishevelled 2, dsh homolog (Drosophila)

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dvl2. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of August 27, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Babayeva S et al. (2011) Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes. Am J Physiol Renal Physiol, 300:F549-60. (PubMed:20534871)
  2. Bouteille N et al. (2009) Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. Oncogene, 28:2569-80. (PubMed:19465938)
  3. Etheridge SL et al. (2008) Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet, 4:e1000259. (PubMed:19008950)
  4. Hamblet NS et al. (2002) Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development, 129:5827-38. (PubMed:12421720)
  5. Hocevar BA et al. (2003) Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J, 22:3084-94. (PubMed:12805222)
  6. Kioussi C et al. (2002) Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 Pathway Mediating Cell-Type-Specific Proliferation during Development. Cell, 111:673-85. (PubMed:12464179)
  7. Kivimae S et al. (2011) All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. BMC Biochem, 12:33. (PubMed:21718540)
  8. Klingensmith J et al. (1996) Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. Mech Dev, 58:15-26. (PubMed:8887313)
  9. Lee JS et al. (1999) Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway. J Biol Chem, 274:21464-70. (PubMed:10409711)
  10. Lee KH et al. (2012) Identification of a novel Wnt5a-CK1varepsilon-Dvl2-Plk1-mediated primary cilia disassembly pathway. EMBO J, 31:3104-17. (PubMed:22609948)
  11. Liu YT et al. (2011) Molecular basis of Wnt activation via the DIX domain protein Ccd1. J Biol Chem, 286:8597-608. (PubMed:21189423)
  12. Luo W et al. (2005) Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J Biol Chem, 280:5054-60. (PubMed:15579909)
  13. Ma L et al. (2010) Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling. J Mol Signal, 5:19. (PubMed:21092292)
  14. Matsuyama M et al. (2009) Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet, 5:e1000427. (PubMed:19300477)
  15. Na J et al. (2007) Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling. Dev Biol, 302:40-9. (PubMed:17005174)
  16. Schwarz-Romond T et al. (2007) Dynamic recruitment of axin by Dishevelled protein assemblies. J Cell Sci, 120:2402-12. (PubMed:17606995)
  17. Suriben R et al. (2009) Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet, 41:977-85. (PubMed:19701191)
  18. Tanaka SS et al. (2013) Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo. PLoS One, 8:e57428. (PubMed:23469192)
  19. Torban E et al. (2004) Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. J Biol Chem, 279:52703-13. (PubMed:15456783)
  20. Wang J et al. (2006) Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development, 133:1767-78. (PubMed:16571627)
  21. Wang J et al. (2005) Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet, 37:980-5. (PubMed:16116426)
  22. Wheeler DS et al. (2011) Direct interaction between NHERF1 and Frizzled regulates beta-catenin signaling. Oncogene, 30:32-42. (PubMed:20802536)
  23. Xue H et al. (2013) Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/beta-catenin signaling. J Biol Chem, 288:15006-14. (PubMed:23580654)
  24. Yamamoto S et al. (2008) Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell, 15:23-36. (PubMed:18606138)
  25. Yokoyama N et al. (2009) Dishevelled-2 docks and activates Src in a Wnt-dependent manner. J Cell Sci, 122:4439-51. (PubMed:19920076)
  26. Zhang Y et al. (2000) Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase. J Biol Chem, 275:25008-14. (PubMed:10829020)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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