Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Vkorc1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Vkorc1
  • participates in the following biological processes:
    • oxidation-reduction process ^[1]
    • vitamin K metabolic process ^[1]
  • performs the following molecular functions:
    • vitamin-K-epoxide reductase (warfarin-sensitive) activity ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Vkorc1
  • participates in the following biological processes:
    • positive regulation of coagulation ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Vkorc1:
  • participates in the following biological processes:
    • drug metabolic process
    • oxidation-reduction process
    • regulation of blood coagulation
    • response to antibiotic
    • response to organic cyclic compound
    • response to organic nitrogen
    • vitamin K biosynthetic process
  • performs the following molecular functions:
    • vitamin-K-epoxide reductase (warfarin-insensitive) activity
    • vitamin-K-epoxide reductase (warfarin-sensitive) activity
  • is located in the following cellular components:
    • endoplasmic reticulum
    • intracellular membrane-bounded organelle

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Vkorc1 indicates that it:
  • performs the following molecular functions:
    • oxidoreductase activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Pelz HJ et al. (2005) The genetic basis of resistance to anticoagulants in rodents. Genetics, 170:1839-47. (PubMed:15879509)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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