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Gene Ontology Classifications
Symbol
Name
ID
Six5
sine oculis-related homeobox 5
MGI:106220

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Six5. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of April 15, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2. [provided by RefSeq, Jul 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Himeda CL et al. (2004) Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer. Mol Cell Biol, 24:2132-43. (PubMed:14966291)
  2. Kawakami K et al. (1996) Identification and expression of six family genes in mouse retina. FEBS Lett, 393:259-63. (PubMed:8814301)
  3. Klesert TR et al. (2000) Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy. Nat Genet, 25:105-9. (PubMed:10802667)
  4. Sarkar PS et al. (2004) Six5 is required for spermatogenic cell survival and spermiogenesis. Hum Mol Genet, 13:1421-31. (PubMed:15163633)
  5. Sarkar PS et al. (2000) Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts. Nat Genet, 25:110-4. (PubMed:10802668)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory