Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dmbt1. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Dmbt1
  • participates in the following biological processes:
    • inner cell mass cell proliferation ^[5]
    • positive regulation of epithelial cell differentiation ^[5]
  • performs the following molecular functions:
    • Gram-negative bacterial cell surface binding ^[4]
    • Gram-positive bacterial cell surface binding ^[4]
    • zymogen binding ^[1]
  • is located in the following cellular components:
    • extrinsic to membrane ^[3]
    • intracellular ^[5]
    • proteinaceous extracellular matrix ^[5]
    • zymogen granule membrane ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Dmbt1
  • participates in the following biological processes:
    • blastocyst development ^[5]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Dmbt1:
  • is located in the following cellular components:
    • cytoplasm
    • extracellular matrix
    • phagocytic vesicle membrane

---

Summary text based on GO annotations supported by structural data

• Dmbt1 encodes a protein or proteins that contain the following InterPro domains: CUB, Speract/scavenger receptor, Speract/scavenger receptor-related, Zona pellucida domain, Zona pellucida domain, conserved site, indicating that the gene product:
  • performs the following molecular functions:
    • scavenger receptor activity
  • is located in the following cellular components:
    • membrane

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Dmbt1 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • protein transport
    • transport
  • is located in the following cellular components:
    • cytoplasmic vesicle
    • extracellular region
    • integral to membrane
    • membrane

---

References

1. Boulatnikov I et al. (2004) Binding of the Golgi sorting receptor muclin to pancreatic zymogens through sulfated O-linked oligosaccharides. J Biol Chem, 279:40918-26. (PubMed:15292166)
2. De Lisle RC. (1994) Characterization of the major sulfated protein of mouse pancreatic acinar cells: a high molecular weight peripheral membrane glycoprotein of zymogen granules. J Cell Biochem, 56:385-96. (PubMed:7876332)
3. De Lisle RC et al. (1997) MUCLIN expression in the cystic fibrosis transmembrane conductance regulator knockout mouse. Gastroenterology, 113:521-32. (PubMed:9247472)
4. Madsen J et al. (2003) CRP-ductin, the mouse homologue of gp-340/deleted in malignant brain tumors 1 (DMBT1), binds gram-positive and gram-negative bacteria and interacts with lung surfactant protein D. Eur J Immunol, 33:2327-36. (PubMed:12884308)
5. Takito J et al. (2004) Conversion of ES cells to columnar epithelia by hensin and to squamous epithelia by laminin. J Cell Biol, 166:1093-102. (PubMed:15452149)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---