Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables protein kinase binding activity; transmembrane signaling receptor activity; and vascular endothelial growth factor binding activity. Involved in several processes, including cell surface receptor signaling pathway; nervous system development; and vasculature development. Acts upstream of or within several processes, including circulatory system development; dichotomous subdivision of terminal units involved in salivary gland branching; and nervous system development. Located in several cellular components, including endosome; focal adhesion; and neurofilament. Is active in glutamatergic synapse and postsynaptic membrane. Is expressed in several structures, including cardiovascular system; jaw; lung; nervous system; and sensory organ. Used to study retinal vein occlusion. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and tetralogy of Fallot. Orthologous to human NRP1 (neuropilin 1).