Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Bcl11a. (This text reflects annotations as of Tuesday, May 21, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Bcl11a
  • performs the following molecular functions:
    • transcription corepressor activity ^[1]
  • is located in the following cellular components:
    • nuclear body ^[2]
    • nucleus ^[1]
• The gene product of Bcl11a has been shown to bind to the gene products of Pias3. ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Bcl11a
  • participates in the following biological processes:
    • B cell differentiation ^[3]
    • negative regulation of gene expression ^[4]
    • protein sumoylation ^[2]
    • T cell differentiation ^[3]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Bcl11a:
  • participates in the following biological processes:
    • negative regulation of collateral sprouting
    • negative regulation of dendrite development
    • negative regulation of neuron projection development
    • positive regulation of collateral sprouting
    • positive regulation of neuron projection development
    • regulation of dendrite development
  • performs the following molecular functions:
    • protein heterodimerization activity
  • is located in the following cellular components:
    • nucleus

---

Summary text based on GO annotations supported by structural data

• Bcl11a encodes a protein or proteins that contain the following InterPro domains: Zinc finger C2H2-type/integrase DNA-binding domain, Zinc finger, C2H2, Zinc finger, C2H2-like, indicating that the gene product:
  • performs the following molecular functions:
    • metal ion binding
    • nucleic acid binding

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Bcl11a indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • cytoplasm

---

References

1. Avram D et al. (2000) Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. J Biol Chem, 275:10315-22. (PubMed:10744719)
2. Kuwata T et al. (2008) BCL11A is a SUMOylated protein and recruits SUMO-conjugation enzymes in its nuclear body. Genes Cells, 13:931-40. (PubMed:18681895)
3. Liu P et al. (2003) Bcl11a is essential for normal lymphoid development. Nat Immunol, 4:525-32. (PubMed:12717432)
4. Sankaran VG et al. (2009) Developmental and species-divergent globin switching are driven by BCL11A. Nature, 460:1093-7. (PubMed:19657335)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---