About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Npm1
nucleophosmin 1
MGI:106184

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Npm1. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 8, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Biggiogera M et al. (1990) Nucleolar distribution of proteins B23 and nucleolin in mouse preimplantation embryos as visualized by immunoelectron microscopy. Development, 110:1263-70. (PubMed:2100262)
  2. Borggrefe T et al. (1998) A B-cell-specific DNA recombination complex. J Biol Chem, 273:17025-35. (PubMed:9642267)
  3. Brady SN et al. (2004) ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway. Mol Cell Biol, 24:9327-38. (PubMed:15485902)
  4. Chen H et al. (2008) Early pre-implantation lethality in mice carrying truncated mutation in the RNA polymerase 1-2 gene. Biochem Biophys Res Commun, 365:636-42. (PubMed:18023416)
  5. Colombo E et al. (2005) Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol, 25:8874-86. (PubMed:16199867)
  6. Crawford NP et al. (2009) The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor. J Biol Chem, 284:28660-73. (PubMed:19710015)
  7. Grisendi S et al. (2005) Role of nucleophosmin in embryonic development and tumorigenesis. Nature, 437:147-53. (PubMed:16007073)
  8. Huang N et al. (2005) Protein NPM3 interacts with the multifunctional nucleolar protein B23/nucleophosmin and inhibits ribosome biogenesis. J Biol Chem, 280:5496-502. (PubMed:15596447)
  9. Kurki S et al. (2004) Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation. Cancer Cell, 5:465-75. (PubMed:15144954)
  10. Lorenzen JA et al. (2005) Rbm19 is a nucleolar protein expressed in crypt/progenitor cells of the intestinal epithelium. Gene Expr Patterns, 6:45-56. (PubMed:16027046)
  11. Ma Z et al. (2006) Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol Cell Biol, 26:9016-34. (PubMed:17015463)
  12. Maggi LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol Cell Biol, 28:7050-65. (PubMed:18809582)
  13. Meder VS et al. (2005) PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli. J Cell Sci, 118:211-222. (PubMed:15615785)
  14. Misawa K et al. (2000) A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc Natl Acad Sci U S A, 97:3062-6. (PubMed:10716735)
  15. Otto J. (1980) Submandibular gland esterproteases. Mouse News Lett, 63:12.
  16. Pang Q et al. (2003) Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR. J Biol Chem, 278:41709-17. (PubMed:12882984)
  17. Romanova LG et al. (2006) Implication of Nucleolar Protein SURF6 in Ribosome Biogenesis and Preimplantation Mouse Development. Biol Reprod, 75:690-6. (PubMed:16855206)
  18. Shinmura K et al. (2005) Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity. FEBS Lett, 579:6621-34. (PubMed:16297385)
  19. Tarapore P et al. (2006) Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing. FEBS Lett, 580:399-409. (PubMed:16376875)
  20. Wu MH et al. (2002) UV stimulation of nucleophosmin/B23 expression is an immediate-early gene response induced by damaged DNA. J Biol Chem, 277:48234-40. (PubMed:12374805)
  21. Yu Y et al. (2006) Nucleophosmin is essential for ribosomal protein L5 nuclear export. Mol Cell Biol, 26:3798-809. (PubMed:16648475)
  22. Yuan X et al. (2005) Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell, 19:77-87. (PubMed:15989966)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory