Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Etfdh. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of July 6, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Electron-transferring-flavoprotein dehydrogenase in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The protein is synthesized as a 67-kDa precursor which is targeted to mitochondria and processed in a single step to a 64-kDa mature form located in the mitochondrial membrane. Deficiency in electron-transferring-flavoprotein dehydrogenase have been demonstrated in some patients with type II glutaricacidemia. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Etfdh
  • participates in the following biological processes:
    • response to oxidative stress ^[1]
  • is located in the following cellular components:
    • mitochondrial inner membrane ^[2]
    • mitochondrion ^{[3, 4]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Etfdh:
  • participates in the following biological processes:
    • electron transport chain
    • fatty acid beta-oxidation using acyl-CoA dehydrogenase
  • performs the following molecular functions:
    • 4 iron, 4 sulfur cluster binding
    • electron carrier activity
    • electron-transferring-flavoprotein dehydrogenase activity
    • iron-sulfur cluster binding
    • oxidoreductase activity
    • quinone binding
    • ubiquinone binding
  • is located in the following cellular components:
    • integral to mitochondrial inner membrane
    • mitochondrial membrane

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Summary text based on GO annotations supported by structural data

• Etfdh encodes a protein or proteins that contain the following InterPro domains: 4Fe-4S ferredoxin-type, iron-sulpur binding domain, Electron transfer flavoprotein-ubiquinone oxidoreductase, Pyridine nucleotide-disulphide oxidoreductase, class-II, indicating that the gene product:
  • participates in the following biological processes:
    • oxidation-reduction process

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Etfdh indicates that it:
  • participates in the following biological processes:
    • oxidation-reduction process
    • transport
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • membrane

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References

1. Chen Y et al. (2006) Redox proteomic identification of oxidized cardiac proteins in adriamycin-treated mice. Free Radic Biol Med, 41:1470-7. (PubMed:17023274)
2. Da Cruz S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J Biol Chem, 278:41566-71. (PubMed:12865426)
3. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
4. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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