Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ppm1g. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ppm1g
  • participates in the following biological processes:
    • cell cycle arrest ^[1]
    • protein dephosphorylation ^[1]
  • performs the following molecular functions:
    • phosphoprotein phosphatase activity ^[1]
  • is located in the following cellular components:
    • nucleus ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ppm1g:
  • participates in the following biological processes:
    • peptidyl-threonine dephosphorylation
  • performs the following molecular functions:
    • protein serine/threonine phosphatase activity
  • is located in the following cellular components:
    • nucleus

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Summary text based on GO annotations supported by structural data

• Ppm1g encodes a protein or proteins that contain the following InterPro domains: Protein phosphatase 2C, Protein phosphatase 2C, manganese/magnesium aspartate binding site, Protein phosphatase 2C-like, indicating that the gene product:
  • performs the following molecular functions:
    • catalytic activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ppm1g indicates that it:
  • participates in the following biological processes:
    • cell cycle
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding

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References

1. Guthridge MA et al. (1997) FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression. Mol Cell Biol, 17:5485-98. (PubMed:9271424)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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